Four meeting talks selected from the Cooper lab this month

Jahnavi presenting at CIS20212

1) Jahnavi discusses the new #IEI associated with TLR8 at the Clinical Immunology Society 2021 Meeting!,
2) Erica presents interesting findings on Tregs in STAT3 Gain-of-function at CIS 2021!,
3) Kelsey presents her work on Th17s and STAT3 at the 2021 AAI meeting
and 4) Maria talks about how NK cells are primed by IL-15 at AAI 2021 meeting! Congratulations to all!

Check out this great review from Erica in Annual Reviews in Immunology (Links to an external site)

Thumbnail of first page of review

Primary immunodeficiency diseases (PIDs) are a rapidly growing, heterogeneous group of genetically determined diseases characterized by defects in the immune system. While individually rare, collectively PIDs affect between 1/1,000 and 1/5,000 people worldwide. The clinical manifestations of PIDs vary from susceptibility to infections to autoimmunity and bone marrow failure. Our understanding of the human immune response has advanced by investigation and discovery of genetic mechanisms of PIDs. Studying patients with isolated genetic variants in proteins that participate in complex signaling pathways has led to an enhanced understanding of host response to infection, and mechanisms of autoimmunity and autoinflammation. Identifying genetic mechanisms of PIDs not only furthers immunological knowledge but also benefits patients by dictating targeted therapies or hematopoietic stem cell transplantation. Here, we highlight several of these areas in the field of primary immunodeficiency, with a focus on the most recent advances.