Genetic basis of pediatric immune dysregulation syndromes
Current projects focused on immune dysregulation include:
- STAT3 gain-of-function
- TLR8 gain-of-function
- Genetic sequencing of novel diseases
- Somatic mutations leading to inborn errors of immunity
Mechanisms of NK cell activation
Current NK cell projects include:
- Metabolic regulation of NK cell activation
- Metabolic regulation of NK cell anti-viral responses
- Enhancing NK cell memory for immunotherapy.