Genetic basis of pediatric immune dysregulation syndromes

Current projects focused on immune dysregulation include:

  • STAT3 gain-of-function
  • TLR8 gain-of-function
  • Genetic sequencing of novel diseases
  • Somatic mutations leading to inborn errors of immunity

Mechanisms of NK cell activation

Current NK cell projects include:

  • Metabolic regulation of NK cell activation
  • Metabolic regulation of NK cell anti-viral responses
  • Enhancing NK cell memory for immunotherapy.